In two small groups of hard-metal workers studied earlier, a weak but still significant inverse correlation was found between exposure time and the left ventricular ejection fraction as measured by radionuclide ventriculography (Horowitz et al. Single cardiomyopathy cases have been reported among persons exposed occupationally to cobalt (Kennedy et al. Systemic Co toxicity manifests as a clinical syndrome with a variable presentation of neurological, cardiovascular, sensitizing, and endocrine symptoms, depending on the systemic Co levels (blood/urine). According to some authors, the most likely effect is the inhibition of cellular respiration due to the inhibition of mitochondrial dehydrogenase (Seghizzi et al. Various pathogenetic mechanisms related to possible cardiac effects have been suspected in hard-metal workers. In vitro experiments have demonstrated that ionized cobalt (Co2 +) is the primary toxic form for systemic toxicity (Leyssens et al. Systemic toxic reactions may arise when Co ions enter the blood and lymphatic circulation and subsequently disseminate to different organs. The toxic potential of cobalt and related health risks have been investigated thoroughly in animal and human toxicity studies. If cobalt exposure affects heart muscle functions at this exposure level, the effects are smaller than those caused by physiological changes due to ageing, medication, and traditional cardiovascular risk factors, such as elevated blood pressure. ConclusionsĪlthough the previous results in 2000 suggested an association between cumulative exposure to cobalt and echocardiographic findings, the results of this new cross-sectional study with a tissue Doppler 6 years later did not confirm the association in the present cohort.
Cobalt exposure symptoms registration#
There were no differences in the laboratory values, the ECG parameters, or the results of the Holter registration of the exposed and unexposed workers. No differences were found between the exposed and unexposed groups for any of the echocardiographic parameters in 2006. Analysis of covariance (ANCOVA) was used to analyse the data. Blood pressure was measured, and electrocardiography (ECG), laboratory tests, Holter registration, and echocardiography were conducted for all participants. Occupational history and health data were collected with a questionnaire. Altogether 93 exposed and 49 non-exposed workers examined in 1999–2000 were re-examined in 2006. The workers’ hearts had been examined by echocardiography in 1999–2000. To study the effect of occupational cobalt exposure on the heart, we conducted a follow-up of workers at a cobalt production plant. The issue of interest for this study is whether cobalt also affects the myocardium at occupational exposure levels. It can cause cardiotoxicity in heavily exposed humans and in experimental systems. September 18, 2022.It has been suspected that cobalt is toxic to the heart. Centers for Disease Control and Prevention. Percentage of Children Aged 1–5 Years With Elevated Blood Lead Levels, by Race/Ethnicity - National Health and Nutrition Examination Survey, United States, 1988–1994, 1999–2006, and 2007–2014.
Gender Differences in the Disposition and Toxicity of Metals. International Journal of Environmental Research and Public Health.
Disparity in Risk Factor Severity for Early Childhood Blood Lead Among Predominantly African-American Black Children: The 1999 to 2010 US NHANES. Genetic and Rare Diseases Information Center. Heavy Metals and Your Health: Frequently Asked Questions About Testing, Treatment and Prevention.National Organization for Rare Disorders.
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